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Effect of Toothpastes on Oral Malodor

NCT07329062 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 52

Last updated 2026-01-09

No results posted yet for this study

Summary

This study aimed to evaluate the effects of different toothpaste formulations on oral malodor in young adults, addressing the lack of clinical evidence regarding propolis- and probiotic-containing toothpastes, which have predominantly been investigated in mouthrinse, tablet, or chewing gum formulations.

Volunteers aged 18-30 years with baseline organoleptic assessment (OA) and Breath Checker® (BC) scores \>0 were randomized into four toothpaste groups: propolis-containing (Glimo Beta), probiotic-containing (Glimo Pi), phosphate-based (Glimo Gamma), and a standard fluoride toothpaste (Sensodyne). Allocation concealment was ensured using identical coded containers, and outcome assessors were blinded. After exclusions, 52 participants completed the study. Oral malodor was evaluated at baseline (T0) and Day 14 (T1) using OA, BC measurements, and self-perceived oral malodor scores.

Conditions

  • Oral Malodor (Halitosis)

Interventions

OTHER

Propolis Containing Toothpaste

Participants were instructed to brush their teeth using propolis toothpaste twice daily (morning and evening) for 14 days as part of their routine oral hygiene.

OTHER

Probiotic containing toothpaste

Participants were instructed to brush their teeth using probiotic toothpaste twice daily (morning and evening) for 14 days as part of their routine oral hygiene.

OTHER

Phosphate-based formulation toothpaste

Participants were instructed to brush their teeth using Phosphate-based formulation toothpaste twice daily (morning and evening) for 14 days as part of their routine oral hygiene.

OTHER

Standard fluoride toothpaste

Participants were instructed to brush their teeth using standard fluoride toothpaste twice daily (morning and evening) for 14 days as part of their routine oral hygiene.

Sponsors & Collaborators

  • Çankırı Karatekin University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-01-30
Primary Completion
2025-06-30
Completion
2025-12-25

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07329062 on ClinicalTrials.gov