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Motor Learning After Cerebellar Damage: The Role of the Primary Motor Cortex

NCT05351255 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 17

Last updated 2025-09-15

No results posted yet for this study

Summary

This study will determine (1) whether baseline inhibitory activity in the primary motor cortex can predict motor learning ability in individuals with cerebellar degeneration, and (2) whether modulating primary motor cortex activity with non-invasive brain stimulation alters motor learning ability in this population.

Conditions

  • Cerebellar Ataxia

Interventions

DEVICE

Transcranial Magnetic Stimulation (TMS)

Aim 2 of the study includes an intervention where participants receive a repetitive TMS protocol called theta burst stimulation (TBS) to study its effect on motor learning behavior.

Sponsors & Collaborators

  • Medical University of South Carolina

    collaborator OTHER

  • Albert Einstein Healthcare Network

    lead OTHER

Principal Investigators

  • Amanda S Therrien, PhD · Moss Rehabilitation Research Institute

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-07-01
Primary Completion
2026-12-19
Completion
2026-12-19

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05351255 on ClinicalTrials.gov