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Microchimerism in Patients With Recurrent Pregnancy Losses

NCT05340556 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 32

Last updated 2025-11-24

No results posted yet for this study

Summary

This pilot study aims to evaluate if microchimeric cells in a patient with recurrent pregnancy loss (RPL) can be detected by the blood analysis for the presence of the DYS14 gene and the use of indel-panel methods and also, to examine if this method can distinguish the cell's origin; comparing gene sequence from the patient's firstborn son or her older brother. In addition, the pilot study will provide the investigators with information and experience necessary for a subsequent main study to be conducted.

Conditions

  • Recurrent Pregnancy Loss, Not Pregnant

Interventions

GENETIC

Blood sample

Blood sample of 12 ml EDTA plasma.

GENETIC

Swap test

receive swab tests for collecting cells from the oral mucosa

Sponsors & Collaborators

  • Department of Clinical Immunology, Odense University Hospital, DK

    collaborator UNKNOWN

  • Aalborg University Hospital

    collaborator OTHER

  • Caroline Nørgaard-Pedersen

    lead OTHER

Principal Investigators

  • Caroline Nørgaard-Pedersen, MD · Aalborg University Hospital, Denmark

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-04-01
Primary Completion
2024-02-05
Completion
2024-02-05

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05340556 on ClinicalTrials.gov