MedTrace Logo

Maternal KIR and Fetal HLA-C Genes in Recurrent Miscarriages

NCT00180804 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 400

Last updated 2023-10-16

No results posted yet for this study

Summary

For implantation of developing conceptus, placental cells need to invade mother's uterus to access maternal blood supply in a control manner. We have found a combination of maternal immune genes (the KIR family) and fetal genes (HLA-C) strongly associated with pre-eclampsia where placenta does not implant adequately. The aim of this research is to investigate these two genes family in women suffering with recurrent miscarriages and find a possible link between them.

Conditions

  • Recurrent Miscarriages

Sponsors & Collaborators

  • Imperial College London

    lead OTHER

Principal Investigators

  • Ashley Moffett, MRCP · University of Cambridge, UK

  • Raj Rai, MRCOG · Imperial College London

  • Preeti Jindal, MRCOG · St. Mary's NHS Trust, London

  • Winnie Lo · St. Mary's NHS Trust, London

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2005-04-30
Completion
2005-08-31

Countries

  • United Kingdom

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00180804 on ClinicalTrials.gov