The Cartagena Cohort Study

Summary

Cardiovascular and respiratory diseases are the first and third cause of death, respectively. Cardiovascular risk is known to increase in groups with impaired lung function; however, the mechanisms behind this association are not fully understood. The aim of CaReS is to elucidate the shared pathophysiology of impaired lung function and cardiovascular risk, and to investigate the risk factors associated with them.

The CaReS Cohort Study includes adults (18-80 years old) from Cartagena de Indias, a tropical city on Colombian Caribbean Coast, where recent population admixture settled a three-hybrid genetic structure (European, African and Ameridian ancestry). At baseline, the cohort will generate extensive data on -omics (e.g., genomics, transcriptomics, metabolomics, and epigenomics), socio-economic wellbeing, lifestyle, medical history, cardiometabolic, inflammatory and liver function markers, as well as objective measures of ventilatory and cardiovascular performance.

The cohort will collect data every three years, for a total period of ten years. Prospective risk of cardiovascular disease and chronic obstructive pulmonary disease (COPD) will be investigated, and their risk factors. Throughout the study period, changes in prevalence, and interactions of various risk factors with these changes will also be ascertained.

A predictive risk score for cardiovascular and chronic respiratory disability will be built, using cross-sectional and longitudinal data.

Conditions

• Cardiovascular Diseases
• COPD
• Lung Function Decreased
• Atherosclerosis

Interventions

GENETIC

Genetic risk variants

Exposure: Genetic predisposition to complex diseases.

OTHER

Diet

Exposure: dietary intake of unhealthy foods known to be associated with higher prevalence of respiratory and cardiovascular diseases.

BEHAVIORAL

Physical activity

Exposure: frequency of moderated or intense physical activity, and daily exposure to sedentary behavior.

OTHER

Socio-economic conditions

Exposure: socio-economic vulnerability indexes associated with higher prevalence of respiratory and cardiovascular diseases (including household conditions, accessibility to health care services, among others).

Sponsors & Collaborators

• The Administrative Department of Science, Technology and Innovation, Colciencias

  collaborator OTHER

• National Center for Research in Chronic Diseases, Colombia

  collaborator UNKNOWN

• Johns Hopkins Bloomberg School of Public Health

  collaborator OTHER

• Universidad Catolica de Cordoba

  collaborator UNKNOWN

• University of Chile

  collaborator OTHER

• Universidad de Sucre

  collaborator UNKNOWN

• Universidad del Magdalena

  collaborator OTHER

• Universidad de Cartagena

  lead OTHER

Principal Investigators

• GUSTAVO J MORA-GARCIA, PhD · Universidad de Cartagena

• VANESSA GARCIA-LARSEN, PhD · BLOOMBERG SCHOOL OF PUBLIC HEALTH JOHNS HOPKINS UNIVERSITY

• MARIA S RUIZ-DIAZ, PhD · NATIONAL CENTER FOR RESEARCH IN CHRONIC DISEASES

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2020-10-03

Primary Completion

2023-10-02

Completion

2034-10-02

Countries

• Colombia

Study Locations