First Live Birth Rate With eSET After Preimplantation Methylome Screening (PIMS) Versus Conventional In-vitro Fertilization

Summary

To determine whether using DNA methylome to select embryos can increase the live birth rate.

Conditions

• Reproductive Techniques, Assisted
• DNA Methylation

Interventions

OTHER

Using DNA methylome to select embryos

DNA methylation level Embryo with methylation level closest to the optimal level (from one couple patients) is the one for embryonic transfer to uterus

OTHER

Using morphologic score to select embryos

blastocyst will transferred according to morphologic score or blastocysts will be biopsied on trophectoderm, sequenced with next-generation sequencing (NGS). Euploidy will transferred one by one according to morphologic score.

Sponsors & Collaborators

• RenJi Hospital

  collaborator OTHER

• Reproductive & Genetic Hospital of CITIC-Xiangya

  collaborator OTHER

• Nanjing Maternity and Child Health Care Hospital

  collaborator OTHER

• ShangHai Ji Ai Genetics & IVF Institute

  collaborator OTHER

• Suzhou Municipal Hospital

  collaborator OTHER

• The First Hospital of Jilin University

  collaborator OTHER

• Sir Run Run Shaw Hospital

  collaborator OTHER

• The Affiliated Hospital Of Guizhou Medical University

  collaborator OTHER

• The Second Hospital of Hebei Medical University

  collaborator OTHER

• Third Affiliated Hospital of Zhengzhou University

  collaborator OTHER

• Ruijin Hospital

  collaborator OTHER

• International Peace Maternity and Child Health Hospital

  collaborator OTHER

• Henan Provincial People's Hospital

  collaborator OTHER

• The First Affiliated Hospital of Hainan Medical University

  collaborator OTHER_GOV

• The First Affiliated Hospital of Anhui Medical University

  collaborator OTHER

• Fujian Maternity and Child Health Hospital

  collaborator OTHER

• General Hospital of Ningxia Medical University

  collaborator OTHER

• The First Affiliated Hospital with Nanjing Medical University

  collaborator OTHER

• 900 Hospital of Joint Logistics Support Force of PLA

  collaborator OTHER

• Guangzhou Womenand Children's Medical Center

  collaborator UNKNOWN

• Changhai Hospital

  collaborator OTHER

• Shenzhen Maternity & Child Healthcare Hospital

  collaborator OTHER

• Sixth Affiliated Hospital, Sun Yat-sen University

  collaborator OTHER

• Liuzhou Hospital of Guangzhou Women and Children's Medical Center

  collaborator UNKNOWN

• Jining Medical University

  collaborator OTHER

• Siriraj Hospital

  collaborator OTHER

• Shandong University

  lead OTHER

Principal Investigators

• Yuan Gao, Professor · Center for Reproductive Medicine, Shandong University

• Yun Sun, Professor · Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine,Shanghai Jiao Tong University

• Ge Lin, Professor · Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA

• Xiufeng Ling, Professor · Department of Reproductive Medicine, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital

• Xiaoxi Sun, Professor · Shanghai Ji Ai Genetics and IVF Institute, Obstetrics and Gynecology Hospital, Fudan University

• Hong Li, Professor · Center for reproduction and genetics,suzhou municipal hospital

• Ruizhi Liu, Professor · Center for Reproductive Medicine, Center for Prenatal Diagnosis First Hospital, Jilin University

• Songying Zhang, Professor · Assisted Reproduction Unit, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine

• Shuyun Zhao, Professor · Center for Reproductive Medicine, The Affiliated Hospital of Guizhou Medical University

• Guimin Hao, Professor · The Second Hospital of Hebei Medical University

• Yichun Guan, Professor · Department of Reproductive Medicine, the Third Affiliated Hospital of Zhengzhou University

• Aijun Zhang, Professor · Reproductive Medical Center of Ruijin Hospital, School of Medicine,Shanghai Jiao Tong University

• Wen Li, Professor · International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University

• Cuilian Zhang, Professor · Reproductive Medical Center, Henan Provincial People's Hospital

• Yanlin Ma, Professor · The First Affiliated Hospital of Hainan Medical University

• Yunxia Cao, Professor · The First Affiliated Hospital of Anhui Medical University

• Beihong Zhen, Professor · Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University

• Junli Zhao, Professor · The General Hospital of Ningxia Medical University

• Xiang Ma, Professor · The First Affiliated Hospital with Nanjing Medical University

• Yun Liu, Professor · 900 Hospital of Joint Logistics Support Force of PLA

• Ling Sun, Professor · Guangzhou Womenand Children's Medical Center

• Hongli Yan, Professor · Changhai Hospital

• Xuemei Li, Professor · Shenzhen Maternity & Child Healthcare Hospital

• Haitao Zeng, Professor · Sixth Affiliated Hospital, Sun Yat-sen University

• Li Fan, Professor · Liuzhou Hospital of Guangzhou Women and Children's Medical Center

• Aijun Yang, Professor · Jining Medical University

• Isarin Thanaboonyawat, Doctor · Siriraj Hospital

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

20 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2022-09-16

Primary Completion

2024-06-01

Completion

2025-05-31

Countries

• China
• Thailand

Study Locations