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Role of Prophylactic Postoperative Antibiotics in HoLEP

NCT05274672 · Status: WITHDRAWN · Phase: PHASE4 · Type: INTERVENTIONAL

Last updated 2026-02-12

No results posted yet for this study

Summary

The purpose of this study is to investigate whether prescribing a 3-day course of antibiotics after Holmium laser enucleation of the prostate (HoLEP) reduces the risk of urinary tract infection. The findings of this trial will have a major impact on clinical practice to either justify the prescription of antibiotics after HoLEP or give urologists more confidence in not prescribing antibiotics prophylactically after HoLEP.

Conditions

Interventions

DRUG

Nitrofurantoin

Prophylactic postoperative antibiotic use

DRUG

Cephalexin

Prophylactic postoperative antibiotic use

DRUG

Sulfamethoxazole Trimethoprim Combination

Prophylactic postoperative antibiotic use

DRUG

Ciprofloxacin

Prophylactic postoperative antibiotic use

PROCEDURE

Holmium Laser Enucleation of prostate

Endoscopic transurethral Holmium Laser enucleation of enlarged prostate followed by morcellation of prostatic tissue

Sponsors & Collaborators

  • Albert Einstein Healthcare Network

    collaborator OTHER

  • Baylor Research Institute

    lead OTHER

Principal Investigators

  • Marawan M. El Tayeb, MD · Baylor Scott and White Health Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
40 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-03-01
Primary Completion
2025-02-20
Completion
2025-02-20
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05274672 on ClinicalTrials.gov