Also known as: chloramphenicol
Ciprofloxacin is a broad-spectrum fluoroquinolone antibiotic used for many bacterial infections across multiple organ systems. It is marketed under brands such as Cipro and is available in oral, intravenous, and topical forms. It is a prescription medicine in the U.S.
JAMA Neurology published Phase 2b PARADIGM results for PrimeC in ALS, showing slower functional decline, fewer ALS-related complications and longer survival. NeuroSense is preparing a Phase 3 trial and received Brazilian patent protection through October 2042.
Researchers used machine learning to identify an antimicrobial peptide, LR, that reduced inflammation and improved gut barrier function in mouse ulcerative colitis. The peptide also reshaped the microbiome and outperformed 5-aminosalicylic acid and ciprofloxacin in the model.
PrimeC, an oral combination therapy, showed safety and signals of clinical benefit in a phase 2b trial, while PLL001, a gut-targeting therapy, demonstrated positive safety and tolerability in a phase I/II study for amyotrophic lateral sclerosis.
A joint report from the European Food Safety Authority and the European Centre for Disease Prevention and Control finds antimicrobial resistance in Salmonella and Campylobacter continues to pose a public health concern across Europe, though several countries have reported progress in reducing resistance levels.
The CDC is investigating a multistate outbreak of extensively drug-resistant Salmonella Newport with an NDM-1 gene linked to Rosabella moringa powder capsules, marking the first documented outbreak of Salmonella with an NDM-1 gene in the United States.
CDC and FDA are investigating a multistate outbreak of extensively drug-resistant Salmonella Newport infections linked to Rosabella brand moringa powder capsules, with seven people sickened across seven states and three requiring hospitalization.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07150065 |
Efficacy of Levofloxacin Versus Ciprofloxacin in the Treatment of Childhood Typhoid Fever |
COMPLETED | PHASE2 |
| NCT07028424 |
PANORAMIX : Optimizing 1st-line NALIRIFOX and Exploring Microbiota's Role in 2nd Line Pancreatic Cancer Treatment |
NOT_YET_RECRUITING | PHASE2 |
| NCT07016165 |
Ciprofloxacin vs Ceftazidime for Empirical Treatment of High-Risk Neutropenic Fever in Children With Hematologic Malignancies |
RECRUITING | PHASE4 |
| NCT06709196 |
Clinical Trial Testing Whether Targeted Antibiotic Prophylaxis Can Reduce Infections After Cystectomy Compared to Empiric Prophylaxis |
RECRUITING | PHASE4 |
| NCT05846399 |
CAT BITE Antibiotic Prophylaxis for the Hand/Forearm (CATBITE) |
RECRUITING | PHASE4 |
| NCT05844735 |
A Randomized Placebo- and Active Comparator-controlled Study to Evaluate the Photosafety of SAR441566 |
COMPLETED | PHASE1 |
| NCT05804123 |
LiveSpo Navax® Supports the Treatment of Acute Rhinosinusitis and Otitis Media |
COMPLETED | NA |
| NCT05462496 |
Modulation of the Gut Microbiome With Pembrolizumab Following Chemotherapy in Resectable Pancreatic Cancer |
RECRUITING | PHASE2 |
| NCT05442736 |
Modified Surface of PLGA Nanoparticles in Smart Hydrogel |
COMPLETED | EARLY_PHASE1 |
| NCT05431673 |
Efficacy Of Doxycycline & Versus Rifampin In Treatment Of Rhinoscleroma |
UNKNOWN | PHASE1 |
