Urinary tract infections are bacterial infections involving the urinary tract, including bladder, urethra, ureters, and kidneys. They are among the most common infections worldwide.
India's drug regulator has mandated stronger safety warnings for doxycycline and carbimazole after a national review of adverse reaction reports. Doxycycline packages will now list potential mental health side effects such as anxiety and dizziness, while carbimazole will warn of a rare blood disorder.
University of Alberta researchers have identified the protease GlpG as a new drug target for antibiotic-resistant E. coli, which causes hundreds of thousands of UTI deaths annually. Inhibiting GlpG prevented bacterial adhesion and biofilm formation in laboratory studies. The discovery addresses a global health emergency as antimicrobial resistance projections show it could cause cancer-level deaths by 2050.
The World Health Organization published blueprints for urgently needed antibiotics targeting drug-resistant infections, while CARB-X awarded $1.2 million for novel antibiotic research and the FDA issued guidance on antibiotic duration limits in livestock.
University of Alberta researchers identified GlpG protease as a new drug target for treating antibiotic-resistant E. coli, which causes 250,000 UTI deaths annually. Inhibiting the protease prevented bacterial adhesion and biofilm formation in laboratory tests.
The CDC is investigating a multistate outbreak of extensively drug-resistant Salmonella Newport with an NDM-1 gene linked to Rosabella moringa powder capsules, marking the first documented outbreak of Salmonella with an NDM-1 gene in the United States.
Obesity contributes to about 1 in every 4 infectious disease deaths in the United States and 1 in 10 globally, according to a major study. People with obesity face 70% higher risk of hospitalization or death from infections, with risk tripling at severe obesity levels.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07702916 |
Effect of Hygiene and Menstrual Hygiene Interventions on Learning and Psychosocial Wellbeing in Madagascar |
ENROLLING_BY_INVITATION | NA |
| NCT07655050 |
Antibiotic Irrigation and Suction Ureteral Access Sheath in RIRS |
RECRUITING | NA |
| NCT07645235 |
A Study to Evaluate Gepotidacin Exposure in Breast Milk of Healthy Lactating Women |
NOT_YET_RECRUITING | PHASE1 |
| NCT07627412 |
WMT for Recurrent Urinary Tract Infections |
COMPLETED | PHASE1/PHASE2 |
| NCT07559318 |
Post-Emergency Optimization of Antibiotic Therapy for Urinary Tract Infection (UTI) |
RECRUITING | |
| NCT07555964 |
Comparing Clean Intermittent Self-catheterization and Indwelling Catheterization for the Management of Urinary Retention Before BPH Surgery. |
NOT_YET_RECRUITING | NA |
| NCT07507851 |
Electroacupuncture for the Prevention of Recurrent Lower Urinary Tract Infection in Women |
NOT_YET_RECRUITING | NA |
| NCT07501065 |
Prophylactic Antibiotics for Outpatient Urethral Bulking |
RECRUITING | PHASE4 |
| NCT07438184 |
Periodontal Therapy and Genitourinary Inflammation in Patients With Prostatitis and Recurrent Urinary Tract Infections |
COMPLETED | NA |
| NCT07435844 |
Effect of Comprehensive Spa Care on Kidney and Urological Conditions: A Clinical Study in Adult Patients |
RECRUITING | NA |
