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Investigating the Anabolic Response to Resistance Exercise After Critical Illness (ARTIST-2)

NCT05261984 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2024-02-20

No results posted yet for this study

Summary

ICU survivors often suffer from long-term functional disability. An attenuated response to physical exercise in skeletal muscle after critical illness may contribute to persisting weakness.

The aim of this study is to investigate the effects of resistance exercise on muscle protein synthesis in former ICU patients. The investigators hypothesize that study subjects recovering from critical illness have an impaired anabolic response to resistance exercise after ICU stay as compared to non-critically ill controls.

Conditions

  • Critical Illness
  • Muscle Loss

Interventions

PROCEDURE

Resistance exercise

Knee extensions in flywheel inertia machine in four sets of 10 repetitions.

DIETARY_SUPPLEMENT

Oral protein supplementation

24 grams of hydrolyzed whey protein.

Sponsors & Collaborators

  • Karolinska University Hospital

    lead OTHER

Principal Investigators

  • Martin Sundström Rehal, MD PhD · Karolinska University Hospital

  • Olav Rooyackers, PhD · Karolinska University Hospital

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-03-08
Primary Completion
2024-01-18
Completion
2024-01-18

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05261984 on ClinicalTrials.gov