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mTOR as Mediator of Insulin Sensitivity Study

NCT05233722 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2024-05-16

No results posted yet for this study

Summary

The study investigates the role of mTOR in mediating enhancement of muscle insulin sensitivity following a single bout of exercise.

This will be investigated in young healthy male subjects by administering the pharmacological mTOR inhibitor Rapamycin in a crossover blinded experimental setup known to enhance muscle insulin sensitivity following one-legged knee-extensor exercise.

Conditions

  • Insulin Sensitivity

Interventions

OTHER

Exercise

1 hour of one-legged knee-extensor exercise followed by 4 hours of rest

PROCEDURE

Insulin infusion

2 hours of Euglycemic Hyperinsulinemic Clamp

DRUG

Placebo

Administration of 800 mg of calcium tablets

DRUG

Rapamycin

Administration of 16 mg of Rapamycin tablets

Sponsors & Collaborators

  • Danish Diabetes Academy

    collaborator OTHER

  • University of Copenhagen

    lead OTHER

Principal Investigators

  • Jørgen FP Wojtaszewski, Professor · Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Denmark

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
22 Years
Max Age
35 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-02-10
Primary Completion
2029-06-30
Completion
2029-06-30

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05233722 on ClinicalTrials.gov