Severe Insulin Resistance in Patients With Type 2 Diabetes
NCT00654056 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 8
Last updated 2013-03-11
Summary
The purpose of the study is to investigate some of the mechanisms behind severe insulin resistance and to determine the dose response to insulin in patients with type 2 diabetes mellitus.
Conditions
Interventions
- DRUG
-
Actrapid (human insulin)
On day one: 0,5 IU/kg/min for 3 hours, 1,5 IU/kg/min for 3 hours, on day two: 3,0 IU/kg/min for 3 hours, 5,0 IU/kg/min for 3 hours
Sponsors & Collaborators
-
Aarhus University Hospital
collaborator OTHER -
Regionshospitalet Silkeborg
collaborator OTHER -
University of Aarhus
lead OTHER
Principal Investigators
-
Niels Moeller, Professor · Department M (Endocrinology and diabetes), Aarhus University Hospital, Nørrebrogade 44, 8000 Århus C, Denmark
Study Design
- Allocation
- RANDOMIZED
- Purpose
- BASIC_SCIENCE
- Masking
- SINGLE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 25 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2008-03-31
- Primary Completion
- 2009-10-31
- Completion
- 2009-10-31
More Related Trials
-
Characterization of the Variability of Insulin Secretory Parameters in the Meal Tolerance and the Maximal Stimulation Tests of Subjects With Type 2 Diabetes Mellitus
NCT01663220 ·Status: COMPLETED
-
Effect of Novel Glucagon Receptor Antagonist REMD-477 on Glucose and Adipocyte Metabolism in T2DM
NCT05093517 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Glucagon Enhanced Insulin Absorption in Diabetes Mellitus Type 1
NCT05960565 ·Status: TERMINATED ·Phase: PHASE2
-
Current Status of Islet Alpha Cell Function in Patients with Type 2 Diabetes
NCT06825182 ·Status: RECRUITING ·Phase: PHASE3
-
Mechanisms of Insulin Resistance in Critical Illness: Role of Systemic Inflammation and GLP-1
NCT01347801 ·Status: COMPLETED ·Phase: NA
-
Endogenous Glucoseproduction in Patients With Type 2 Diabetes Mellitus During Oral Glucose and iv. Glucose Infusion
NCT02010827 ·Status: COMPLETED
-
Influence of Central Nervous Insulin Sensitivity on Insulin Secretion
NCT02870361 ·Status: COMPLETED ·Phase: NA
-
The Effect of Hyperglycemia on LV Function and Exercise Capacity in Diabetics With and Without Heart Failure.
NCT01071772 ·Status: COMPLETED ·Phase: PHASE2
-
Alpha-Cell Sensitivity to GLP-1 in Patients With Type 2 Diabetes
NCT00497133 ·Status: COMPLETED
-
Peripheral Metabolic Effects of Ghrelin
NCT00771940 ·Status: COMPLETED ·Phase: PHASE1
-
Characterization of the Variability Of Insulin Secretory Parameters in the Meal Tolerance and the Maximal Stimulation Tests of Subjects With Prediabetes
NCT01663207 ·Status: COMPLETED
-
Cardiovascular Effects of Rapidly Declining Plasma Glucose in Patients With Type 1 Diabetes
NCT04800536 ·Status: COMPLETED ·Phase: NA
-
Impact of INsulin Sensitivity on Cardiovascular Risk Markers During 10-20 Years of FOllow up
NCT01412554 ·Status: COMPLETED
-
Metabolic Signalling in Muscle- and Adipose-tissue Following Insulin Withdrawal and Growth Hormone Injection.
NCT02077348 ·Status: COMPLETED ·Phase: NA
-
Modulation of Human Myocardial Metabolism by GLP-1 Dose Response
NCT01607450 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Central Insulin Sensitivity in Individuals With Type 2 Diabetes (T2D) and at Risk for Developing T2D
NCT05856877 ·Status: RECRUITING ·Phase: NA
-
Insulin Secretion in Diabetes Before and After Glycemic Control
NCT00469833 ·Status: COMPLETED ·Phase: NA
-
Glucagon Resistance in Patients With NAFLD
NCT04042142 ·Status: COMPLETED ·Phase: NA
-
Insulin Therapy in Type 2 Diabetic Patients: Real-life Study on Effectiveness and Satisfaction
NCT06117449 ·Status: NOT_YET_RECRUITING
-
A Research Study to Understand How Oral Semaglutide Works in People With Type 2 Diabetes in India
NCT05502562 ·Status: COMPLETED
-
Early Diabetes Intervention Program
NCT01470937 ·Status: COMPLETED ·Phase: PHASE4
-
VLDL-triglyceride Kinetics in Type 2 Diabetes
NCT01037647 ·Status: COMPLETED
-
Characterization of the Variability of Insulin Secretory Parameters in the Meal Tolerance and the Maximal Stimulation Tests of Healthy Subjects
NCT01454973 ·Status: COMPLETED
-
Study of Recombinant Human Insulin-Like Growth Factor I in Patients With Severe Insulin Resistance
NCT00004419 ·Status: COMPLETED ·Phase: NA
-
Hepatic Metabolic Changes in Response to Glucagon Infusion
NCT03526445 ·Status: COMPLETED ·Phase: NA