RTX-224 Monotherapy in Patients With Solid Tumors
NCT05219578 · Status: TERMINATED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 7
Last updated 2022-12-09
Summary
This is an open-label, multidose, first-in-human (FIH), Phase 1/2 study of RTX-224 for the treatment of patients with relapsed or refractory (R/R), or locally advanced solid tumors.
Conditions
- Non Small Cell Lung Cancer
- Cutaneous Melanoma
- Head and Neck Squamous Cell Carcinoma
- Urothelial Carcinoma
- TNBC - Triple-Negative Breast Cancer
Interventions
- DRUG
-
RTX-224
RTX-224 monotherapy
Sponsors & Collaborators
-
Rubius Therapeutics
lead INDUSTRY
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SEQUENTIAL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2022-01-12
- Primary Completion
- 2022-11-30
- Completion
- 2022-11-30
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
A Study of JNJ-89862175 for Treatment of Advanced Solid Tumors
NCT07223125 ·Status: RECRUITING ·Phase: PHASE1
-
A Phase I Clinical Study With Investigational Compound LTT462 in Adult Patients With Specific Advanced Cancers.
NCT02711345 ·Status: TERMINATED ·Phase: PHASE1
-
A Study of YL242 in Subjects With Advanced Solid Tumors
NCT07197827 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Safety and Pharmacokinetic Study of RRx-001 in Cancer Subjects
NCT01359982 ·Status: COMPLETED ·Phase: PHASE1
-
Safety, Tolerability, PK, Dosimetry, MTD and Preliminary Efficacy of Intra-lesionally Injected AvidinOX, Followed by IV Escalating Doses of [177Lu]DOTA-biotin in Pts With Injectable Solid Tumors or Lymphomas
NCT03188328 ·Status: TERMINATED ·Phase: PHASE1
-
Study to Assess Safety, Tolerability and PK of AZD1480 in Patients With Solid Tumours
NCT01112397 ·Status: TERMINATED ·Phase: PHASE1
-
A Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of TT125-802 in Subjects With Advanced Solid Tumors
NCT06403436 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
XTX202 in Patients With Advanced Solid Tumors
NCT05052268 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors
NCT03517488 ·Status: COMPLETED ·Phase: PHASE1
-
ATI-2231 in Advanced Solid Tumor Malignancies
NCT05791474 ·Status: WITHDRAWN ·Phase: PHASE1
-
Safety Study of AMG 228 to Treat Solid Tumors
NCT02437916 ·Status: TERMINATED ·Phase: PHASE1
-
Oral Immunomodulatory Tyrosine Kinase Inhibitor in Patients With Locally Advanced or Metastatic Solid Tumors
NCT03454243 ·Status: TERMINATED ·Phase: EARLY_PHASE1
-
A Study Of PF-06647263 In Patients With Advanced Solid Tumors
NCT02078752 ·Status: TERMINATED ·Phase: PHASE1
-
Study Evaluating TTI-237 in Advanced Malignant Solid Tumors
NCT00195247 ·Status: TERMINATED ·Phase: PHASE1
-
Phase 1/2a Dose-Escalation Study of CRLX301 in Patients With Advanced Solid Tumors
NCT02380677 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Safety, Tolerability, and Immunogenicity of mRNA-4157 Alone and in Combination in Participants With Solid Tumors
NCT03313778 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
A Clinical Study of Purinostat Mesylate for Injection in Patients With Advanced Solid Tumors
NCT06431243 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Study of DS-2248 in Participants With Advanced Solid Tumors
NCT01288430 ·Status: TERMINATED ·Phase: PHASE1
-
Study of Robatumumab (SCH 717454, MK-7454) in Combination With Different Treatment Regimens in Participants With Advanced Solid Tumors (P04722, MK-7454-004)
NCT00954512 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Safety and Pharmacologic Study of VTX-2337 in Patients With Advanced Cancer
NCT00688415 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase 1 Study of RO7623066 Alone and in Combination in Patients With Advanced Solid Tumors
NCT05240898 ·Status: COMPLETED ·Phase: PHASE1
-
MSX-122 Administered Orally in Patients With Refractory Metastatic or Locally Advanced Solid Tumors
NCT00591682 ·Status: SUSPENDED ·Phase: PHASE1
-
A Study of PTS for Patients With Solid Tumors
NCT03448211 ·Status: WITHDRAWN ·Phase: PHASE1
-
A Phase I Study of PM02734 in Subjects With Advanced Malignant Solid Tumors
NCT00404521 ·Status: TERMINATED ·Phase: PHASE1
-
BGB-15025 Alone and in Combination With Anti-PD-1 Monoclonal Antibody Tislelizumab in Participants With Advanced Solid Tumors
NCT04649385 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1