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Parasitism & COVID19 Vaccines: New Challenge.

NCT05185778 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 128

Last updated 2022-04-01

No results posted yet for this study

Summary

\- Parasitic infection is a serious public health problem throughout the world particularly in developing countries including Egypt. The individuals infected with helminths are responding to the parasite infections by a specific Th2 type innate and adaptive immune responses. The Coronavirus Disease 2019 pandemic has affected over 169 million people and caused the death of millions worldwide. COVID vaccines with up to 95% of efficacy and effectiveness have been developed and approved by the Food and Drug Administration (FDA), USA. Moreover, it's reported that vaccination against COVID may lead to Cytokine Storm Syndrome in some vaccinated people with release of large amounts of cytokines as (IFNγ, IL-12, TNFα).

Conditions

  • Helminths Infection
  • Protozoan Infections

Interventions

BIOLOGICAL

stool examination, blood sample collected

Stool examination macroscopically for consistency, color, and presence of blood and/or mucus and microscopically using the following methods: * Saline and iodine wet mount. * Formalin-ethyl acetate sedimentation method. * Modified Ziehl-Nielsen staining : It was done to all cases with manifestations suggestive of protozoa. * Collection of peripheral blood samples for Automated CBC and blood indices evaluation. * Molecular detection of inflammatory cytokines level (IFNγ, TNFα) and antiinflammatory cytokines (IL4, IL10) by Real-time PCR(polymerase chain reaction).

Sponsors & Collaborators

  • Assiut University

    lead OTHER

Eligibility

Min Age
15 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-04-01
Primary Completion
2024-10-30
Completion
2025-10-30
FDA Drug
Yes

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05185778 on ClinicalTrials.gov