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Repeated Controlled Human Schistosoma Mansoni Infection

NCT05085470 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2023-01-30

No results posted yet for this study

Summary

A group of 24 healthy volunteers are challenged one or three times with 20 male Schistosoma mansoni cercariae to investigate whether this leads to protection and to identify potential correlates of protection

Conditions

  • Schistosomiasis
  • Schistosoma Mansoni

Interventions

BIOLOGICAL

Schistosoma mansoni infection

20 viable male Schistosoma mansoni cercariae of the Puerto Rican strain

BIOLOGICAL

Placebo mock infection

Placebo mock infection with water

Sponsors & Collaborators

  • Leiden University Medical Center

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-10-29
Primary Completion
2023-01-11
Completion
2023-01-11

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05085470 on ClinicalTrials.gov