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Long-Term Effects of Repetitive, Low-Level Blast Exposure on Special Operations Forces Service Members

NCT05183087 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2023-04-04

No results posted yet for this study

Summary

This is a pilot study to identify biomarkers that individually, and in combination, demonstrate the greatest sensitivity to repetitive, low-level blast exposure (RLLBE) neurotrauma in Special Operations Forces (SOF) personnel. The proposed cross-sectional, multimodal study will elucidate the potential effects of long-term RLLBE by comparing biomarkers across subjects.

Conditions

Interventions

DIAGNOSTIC_TEST

3T Connectome MRI

MRI scan of structural connectivity

DIAGNOSTIC_TEST

7 Tesla MRI

MRI scan of functional connectivity

DIAGNOSTIC_TEST

TSPO PET

PET scan of neuroinflammation

DIAGNOSTIC_TEST

Tau PET

PET scan of tau deposition

DIAGNOSTIC_TEST

Cognitive and Behavioral Assessments

Assessments of memory, attention, complex reasoning, mood and other cognitive/behavioral domains

DIAGNOSTIC_TEST

Blood Biomarkers

Blood-based assessments of proteomic and metabolic biomarkers of brain injury

Sponsors & Collaborators

  • Massachusetts General Hospital

    lead OTHER

Principal Investigators

  • Brian L Edlow, M.D. · Massachusetts General Hospital

Eligibility

Min Age
25 Years
Max Age
45 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-07-01
Primary Completion
2023-02-28
Completion
2023-02-28

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05183087 on ClinicalTrials.gov