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Characteristics and Outcomes of Patients With COVID-19 Treated With HFNO and Prone Positioning

NCT05178212 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 600

Last updated 2026-01-27

No results posted yet for this study

Summary

A subset of patients with COVID-19 develops acute respiratory failure and acute respiratory distress syndrome (ARDS) (1). The use of invasive mechanical ventilation for the treatment of these conditions is associated with high mortality rates (2,3). The use of high-flow nasal oxygen therapy (HFNO) and awake prone position (AW-PP) could to decrease the need for endotracheal intubation and other adverse clinical outcomes (4-6).

The aim of this study is to evaluate the clinical results of the simultaneous application of high-flow nasal oxygen therapy HFNO and awake-prone position in a cohort of patients with severe respiratory failure secondary to COVID-19 on relevant clinical outcomes, and to assess risk factors of treatment failure defined as requirement of invasive mechanical ventilation.

Conditions

Sponsors & Collaborators

  • Hospital Aleman

    collaborator OTHER

  • Austral University, Argentina

    collaborator OTHER

  • Hospital Privado de Comunidad de Mar del Plata

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-04-15
Primary Completion
2021-12-30
Completion
2022-12-31

Countries

  • Argentina

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05178212 on ClinicalTrials.gov