Multidisciplinary Expert System for the Assessment & Management of Complex Brain Disorders

Summary

The Multidisciplinary Expert System for the Assessment \& Management of Complex Brain Disorders (MES-CoBraD) is an interdisciplinary project combining Real-World Data (RWD) from multiple clinical and consumer sources through comprehensive, cost-efficient, and fast protocols towards improving diagnostic accuracy and therapeutic outcomes in people with Complex Brain Disorders (CoBraD), as reflected in Neurocognitive (Dementia), Sleep, and Seizure (Epilepsy) disorders and their interdependence. It brings together internationally recognized experts in medicine, engineering, computer science, social health science, law, and marketing and communication from across Europe, and combines clinical information and scientific research in CoBraD with technical innovation in secure data-sharing platforms, artificial intelligence algorithms, and expert systems of precision and personalized care, with a primary focus on improving the quality of life of patients, their caregivers, and the society at large. It leverages RWD from diverse CoBraD populations across cultural, socioeconomic, educational, and health system backgrounds, with special attention on including vulnerable populations and minorities in an equitable manner and engaging key stakeholders to maximize project impact.

Conditions

• Dementia
• Alzheimer Disease
• Epilepsy
• Sleep Disorder
• Circadian Rhythm Disorders
• Healthy

Interventions

DIAGNOSTIC_TEST

EEG,PSG

concurrent overnight sleep study with full electroencephalography (in-lab or at home)

DIAGNOSTIC_TEST

biosample collection (blood and CSF)

blood or CSF collection for analyses of neurodegenerative, inflammatory, and, per condition, genetic information

DIAGNOSTIC_TEST

neuropsychological testing

paper and pencil, as well as tablet based cognitive testing

DIAGNOSTIC_TEST

actigraphy

week long actigraphy assessment with concurrent sleep diary acquisition

DIAGNOSTIC_TEST

clinician assessment

standard clinical assessment by an expert clinician in the respective field of brain disorders

Sponsors & Collaborators

• Rabin Medical Center

  collaborator OTHER

• Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

  collaborator OTHER

• King's College London

  collaborator OTHER

• Uppsala University

  collaborator OTHER

• Holistic IKE

  collaborator UNKNOWN

• National Technical University of Athens

  collaborator OTHER

• Evolution Projects

  collaborator UNKNOWN

• Engineering Ingegneria Informatica S.p.A.

  collaborator UNKNOWN

• SOFTWARE IMAGINATION & VISION SRL

  collaborator UNKNOWN

• Vrije Universiteit Brussel

  collaborator OTHER

• STICHTING LIBER

  collaborator UNKNOWN

• University of Edinburgh

  collaborator OTHER

• CyberEthics Lab. srls

  collaborator UNKNOWN

• Neurological Institute of Athens

  lead OTHER

Principal Investigators

• Elissaios Karageorgiou · Neurological Institute of Athens

• Ioannis Stavropoulos · King's College London

• Ophir Keret · Rabin Medical Center

• Juan Fortea · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Eligibility

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2021-04-01

Primary Completion

2024-09-30

Completion

2024-09-30

Countries

• Greece
• Israel
• Spain
• United Kingdom

Study Locations