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Exploration of the Deep Transcranial Magnetic Stimulation for Treatment Resistant Schizophrenia

NCT05167942 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 87

Last updated 2021-12-22

No results posted yet for this study

Summary

Negative symptoms and cognitive dysfunction are of importance for the prognosis of the patients of schizophrenia. Based on the hypothesis that deep transcranial magnetic stimulation(dTMS) on prefrontal cortex #PFC# could down-regulate the glutamate level of PFC and regulate the functional network in patients with treatment resistance schizophrenia,this research plan to utilise multimodal functional magnetic imaging method(including structural MRI,resting-state functional magnetic resonance imaging and 1H-MRS) to investigate therapeutic efficacy of high-frequency deep transcranial magnetic stimulation on SZ patients symptoms,as well as to elucidate the correlation between treatment effects and glutamate level of PFC

Conditions

  • Treatment Resistant Schizophrenia Based on the DTMS

Interventions

DEVICE

deep transcranial magnetic stimulation with H1 coil

Sham deep transcranial magnetic stimulation on PFC .Duration:40 days.

DEVICE

High frequency deep transcranial magnetic stimulation with H1 coil

high frequency(20Hz) deep transcranial magnetic stimulation on PFC .Duration:40 days.

DEVICE

iTBS deep transcranial magnetic stimulation with H1 coil

iTBS deep transcranial magnetic stimulation on PFC .Duration:40 days.

Sponsors & Collaborators

  • Shanghai Mental Health Center

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-11-01
Primary Completion
2023-09-30
Completion
2023-09-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05167942 on ClinicalTrials.gov