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Repetitive Transcranial Magnetic Stimulation in Early Psychosis and The Functional Connectivity Biotypes

NCT04853485 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 300

Last updated 2023-12-29

No results posted yet for this study

Summary

The present study plans to explore different cortical targets of repetitive transcranial magnetic stimulation (rTMS) for populations at the early phase of psychosis, including those at clinical high risk of psychosis and in the first episode of psychosis. The clinical augmentation efficacy will be associated with the brain functional connectivity of these populations.

Conditions

  • Schizophrenia; Psychosis
  • First Episode Psychosis
  • Clinical High Risk

Interventions

DEVICE

repetitive transcranial magnetic stimulation (rTMS)

All subjects with early psychosis will be divided into three subgroups determined by their psychotic symptoms and cognition. There are three rTMS strategies: (1) For subgroup 1, characterized by negative symptoms, iTBS over cerebellum and 1 Hz over right DLPFC; (2) For subgroup 2, characterized by cognition deficits, 20 Hz over the left inferior parietal cortex; (3) For subgroup 3, characterized by positive symptoms: 10 Hz over ACC. Ten to twenty sessions of rTMS will be delivered to each patients during the intervention period.

Sponsors & Collaborators

  • Suzhou Psychiatric Hospital

    collaborator OTHER

  • Guangzhou Psychiatric Hospital

    collaborator OTHER_GOV

  • Shenzhen Kangning Hospital

    collaborator OTHER

  • Tianjin Anding Hospital

    collaborator OTHER

  • Nantong Fourth People's Hospital & Nantong Brain Hospital

    collaborator UNKNOWN

  • Shanghai Jiao Tong University School of Medicine

    lead OTHER

Principal Investigators

  • Jijun Wang, M.D., Ph.D · Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
14 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-08-01
Primary Completion
2023-12-31
Completion
2024-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04853485 on ClinicalTrials.gov