Polysomnographic Titration of Non-invasive Ventilation in Motor Neurone Disease

Summary

A two-arm, individual participant randomised controlled, assessor-blinded trial in 7 MND care centres across Australia will be undertaken.

Conditions

• Motor Neuron Disease / Amyotrophic Lateral Sclerosis

Interventions

OTHER

Intervention polysomnography

Please refer to 'Arms: Intervention' section.

OTHER

Sham polysomnography

Please refer to 'Arms: Control' section.

Sponsors & Collaborators

• Austin Hospital, Melbourne Australia

  collaborator OTHER

• Institute for Breathing and Sleep, Australia

  collaborator OTHER

• Royal Prince Alfred Hospital, Sydney, Australia

  collaborator OTHER

• Macquarie University, Australia

  collaborator OTHER

• Macquarie Health

  collaborator UNKNOWN

• Western Sydney Local Health District

  collaborator OTHER

• Flinders Medical Centre

  collaborator OTHER_GOV

• Sir Charles Gairdner Hospital

  collaborator OTHER

• The Prince Charles Hospital

  collaborator OTHER_GOV

• Monash University

  collaborator OTHER

• Motor Neurone Disease Australia

  collaborator UNKNOWN

• FightMND

  collaborator OTHER

• Australian Motor Neurone Disease Registry

  collaborator UNKNOWN

• Calvary Bethlehem

  collaborator UNKNOWN

• Perron Institute for Neurological and Translational Science

  collaborator OTHER

• University of Melbourne

  lead OTHER

Principal Investigators

• Abbey Sawyer, PhD · University of Melbourne

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-12-15

Primary Completion

2026-02-28

Completion

2028-02-28

Countries

• Australia

Study Locations