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Assessing Ventilator Safety in Patients on Pressure-Support Ventilation

NCT05125952 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 16

Last updated 2025-10-15

Study results available
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Summary

ASOP is a prospective cohort study comparing three methods for assessing risk of self-induced lung injury in patients with acute respiratory failure being managed with pressure-support ventilation. We will describe the relationship between three different assessment methods for risk of self-induced lung injury and compare them to a gold standard measurement.

Conditions

  • Acute Respiratory Failure
  • Mechanical Ventilation Complication
  • Ventilator-Induced Lung Injury

Interventions

DEVICE

Viasys Avea Ventilator

Measuring dynamic airway driving pressure and static airway driving pressure during pressure support breath, and static airway driving pressure during a volume control breath. Measuring airway occlusion pressure during pressure support breath.

DEVICE

Philips Respironics NM3 device

Measuring static airway driving pressure during pressure support breath

DEVICE

Servo U ventilator

Measuring static airway driving pressure and p0.1 during pressure support breath.

DEVICE

Vyaire SmartCath adult nasogastric tube with Esophageal balloon

Measuring static and dynamic esophageal driving pressure during pressure support breath, and esophogeal pressure change during airway occlusion maneuver.

Sponsors & Collaborators

Principal Investigators

  • Neil R MacIntyre, MD · Professor of Medicine

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-02-08
Primary Completion
2023-11-21
Completion
2023-12-21
FDA Device
Yes

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05125952 on ClinicalTrials.gov