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Trial of Preoperative Radiosurgery Versus Postoperative Stereotactic Radiotherapy for Resectable Brain Metastases

NCT05124236 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 200

Last updated 2026-03-04

No results posted yet for this study

Summary

The research question is whether a single fraction of preoperative radiosurgery can reduce the incidence of leptomeningeal disease 12 months following resection of a brain metastasis (BM) as compared with 5 fractions of postoperative stereotactic radiotherapy.

Conditions

  • Brain Metastases, Adult

Interventions

RADIATION

preoperative radiosurgery

single fraction radiosurgery

RADIATION

postoperative hypofractionated stereotactic radiotherapy

fractionated stereotactic radiotherapy /radiosurgery in 1 to 6 fractions according to local standard of care

Sponsors & Collaborators

  • University of Basel

    collaborator OTHER

  • Susanne Rogers

    lead OTHER

Principal Investigators

  • Susanne Rogers, MD PhD · Kantonsspital Aarau, Radio-Onkologie-Zentrum Mittelland

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-07-29
Primary Completion
2028-12-30
Completion
2028-12-30

Countries

  • Austria
  • Germany
  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05124236 on ClinicalTrials.gov