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Impact of Prescription Quality, Infection Control and Antimicrobial Stewardship on Gut Microbiota Domination by Healthcare-Associated Pathogens

NCT03765528 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 1500

Last updated 2020-08-03

No results posted yet for this study

Summary

Extended-spectrum beta-lactamase producing Enterobacteriaceae (EPE), vancomycin-resistant enterococci (VRE) and Clostridium difficile have become a major threat to hospitalised patients worldwide. We hypothesize that receiving inappropriate antibacterial treatment places patients at high risk of intestinal domination and subsequent infection by these bacteria. Further analyses will address cost-effectiveness of specific interventions, behavioural analyses of the decision process leading to inappropriate antibacterial treatment, and the rate of undetected colonization with EPE/VRE/C. difficile on admission.

Conditions

  • Patients at High Risk of Antibacterial Treatment Upon Admission

Sponsors & Collaborators

  • University Hospital of North Norway

    collaborator OTHER

  • Karolinska Institutet

    collaborator OTHER

  • Rabin Medical Center

    collaborator OTHER

  • University of Latvia

    collaborator OTHER

  • McGill University Health Centre/Research Institute of the McGill University Health Centre

    collaborator OTHER

  • Haukeland University Hospital

    collaborator OTHER

  • University Hospital, Akershus

    collaborator OTHER

  • Helse Stavanger HF

    collaborator OTHER_GOV

  • Goethe University

    collaborator OTHER

  • University Hospital of Cologne

    lead OTHER

Principal Investigators

  • Jörg Janne Vehreschild, MD · University Hospital Cologne

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-01-01
Primary Completion
2021-07-31
Completion
2022-07-31

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03765528 on ClinicalTrials.gov