MedTrace Logo

The Role of Cathepsin X in Infection With the Helicobacter Pylori

NCT01137942 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 14

Last updated 2010-07-12

No results posted yet for this study

Summary

The immune response to Helicobacter pylori (Hp) importantly determines the pathogenesis of infection as well as the success of antibiotic eradication of the bacteria. The investigators want to demonstrate the importance of cathepsin X (CTSX), a cysteine protease, for the Hp eradication success. The diversity of the innate immune response to H. pylori antigens leading to either successful eradication of the infection or maintenance of chronic inflammation is connected to CTSX. The aim of this study is to determine whether H. pylori suppresses the CTSX expression and cytokine secretion in macrophage cell line THP-1 in the individuals that are not capable of eradicating the infection, opposite to H pylori in patients with successful H pylori eradication . The investigators also investigate the possibility whether strain-dependent differences in H. pylori lipopolysaccharide (LPS) influence the CTSX expression and cytokine secretion.

Conditions

  • Persistence of Infection With Helicobacter Pylori

Interventions

DRUG

clarithromycin, metronidazole, proton pump inhibitor

appropriate dose of antibiotics and proton pump inhibitor

Sponsors & Collaborators

  • University Medical Centre Ljubljana

    lead OTHER

Principal Investigators

  • Alojz Ihan, MD, PhD · Institute of microbiology and immunology, Ljubljana, Slovenia

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-11-30
Primary Completion
2009-12-31
Completion
2010-07-31

Countries

  • Slovenia

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01137942 on ClinicalTrials.gov