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Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans

NCT05120635 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2025-12-16

No results posted yet for this study

Summary

Anxiety disorders such as post-traumatic stress disorder (PTSD) and generalized anxiety disorder (GAD) affect a large number of individuals with a significant portion of patients failing to improve with current treatments.

The purpose of this study is to understand the brain mechanisms that produce fear and anxiety in humans. To accomplish this goal, we will measure the brain activity along with the heart rate and skin perspiration of patients while they are completing tasks on a computer. Some of the tasks will also use a virtual reality headset and transport the patient in a video game-like environment. These tasks will expose the participants to various levels of fear-provoking images. Participants with responsive neurostimulation (RNS) implants will be enrolled under Pro00117931 at Duke, but their results for fear and anxiety tasks will be reported under NCT05120635.

Conditions

  • Fear
  • GAD
  • Emotional Memory
  • PTSD

Interventions

DEVICE

Deep Brain Stimulation

Deep brain stimulation will be used

BEHAVIORAL

Virtual and augmented reality tasks

Virtual and augmented reality tasks will be used.

Sponsors & Collaborators

  • National Institutes of Health (NIH)

    collaborator NIH

  • VA Greater Los Angeles Healthcare System

    collaborator FED

  • NeuroPace

    collaborator INDUSTRY

  • National Institute of Mental Health (NIMH)

    collaborator NIH

  • Duke University

    lead OTHER

Principal Investigators

  • Nanthia Suthana, PhD · Duke Health

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-10-01
Primary Completion
2026-06-30
Completion
2026-06-30

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05120635 on ClinicalTrials.gov