Sequelae of COVID-19 With Focus on Exercise Capacity and Underlying Mechanisms

Summary

The project is designed as a cross-sectional study and aims to examine long-term consequences of coronavirus disease 2019 (COVID-19) for selected bio-behavioural parameters while taking the disease course severity into account.

Conditions

• Patients Post-COVID-19
• Controls

Interventions

DIAGNOSTIC_TEST

Cardiorespiratory fitness

Cardiopulmonary exercise testing

DIAGNOSTIC_TEST

Lung function

Body plethysmography

DIAGNOSTIC_TEST

Muscular strength and balance tests

Handgrip strength test, mid-thigh pull test and standing balance test in static tandem stance

DIAGNOSTIC_TEST

Micro- and macrovascular endothelial function and cardiac function

Measurement of flow-mediated dilation, static and dynamic retinal vessel analysis, echocardiography

DIAGNOSTIC_TEST

Blood sampling and analysis

Blood sampling by venepuncture

DIAGNOSTIC_TEST

Physical activity

Physical activity surveillance using accelerometers

DIAGNOSTIC_TEST

Questionnaires

Global physical activity questionnaire (GPAQ), short-form 8 health survey (SF-8), barriers to physical activity, fatigue assessment scale (FAS), modified medical research council dyspnea scale (mMRC), depression, anxiety, and stress scale (DASS21), post-COVID-19 syndrome symptoms

DIAGNOSTIC_TEST

Body composition

Dual-energy x-ray absorptiometry (DXA)

Sponsors & Collaborators

• Arno Schmidt-Trucksäss

  lead OTHER

Principal Investigators

• Arno Schmidt-Trucksäss, Prof. · Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland

Eligibility

Min Age

40 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-01-03

Primary Completion

2024-03-31

Completion

2024-03-31

Countries

• Switzerland

Study Locations