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Detection of Schistosomiasis CAA in Travellers After High-risk Water Contact

NCT02194712 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 106

Last updated 2020-11-18

No results posted yet for this study

Summary

Schistosomiasis is increasingly encountered among travellers returning from the tropics and is known for its focal endemicity, associated with the presence of the snail intermediate host in fresh water. Because schistosomiasis in travellers is often atypical or asymptomatic due to the low intensity of infection, many infections likely go undiagnosed and will develop into chronic schistosomiasis. Conventional treatment of schistosomiasis in travellers with praziquantel 40mg/kg daily dose is known for its modest success rate. Diagnosis of schistosomiasis relies on egg detection, which has a poor sensitivity in low burden infections, or serology, which is inadequate to monitor cure. The department of parasitology of the Leiden University Medical Center has developed a novel diagnostic test based on the up-converting phosphor technology (UCP) to detect circulating anodic antigen (CAA). This test can be performed on serum and urine to detect low intensity schistosomiasis infections and confirm cure after praziquantel treatment. This study will assess the performance of UCP-CAA in travellers with high-risk water contact.

Conditions

  • Schistosomiasis

Interventions

OTHER

Urine CAA detection

In addition to routine diagnostics, serum and urine samples are stored for retrospective UCP-CAA antigen determination.

Sponsors & Collaborators

  • Meta Roestenberg

    lead OTHER

Principal Investigators

  • M.P. Grobusch, Prof. MD. PhD · Amsterdam UMC, location VUmc

  • P.J.J. van Genderen, MD, PhD · Harbour Hospital Rotterdam

  • M. Roestenberg, MD. PhD. · Leiden University Medical Center

Eligibility

Min Age
18 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-01-31
Primary Completion
2019-09-30
Completion
2019-09-30

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02194712 on ClinicalTrials.gov