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Study of the Effects of Adolescent Weight Disorders (Obesity, Anorexia Nervosa) on Heart Function

NCT05071157 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 87

Last updated 2023-01-18

No results posted yet for this study

Summary

The study aims to better understand the functioning of the heart of children and adolescents with anorexia nervosa or obesity, compared to the heart function of control subject. This project seeks to find out if a weight disorder affects the heart and whether a systematic cardiac assessment with appropriate management is then to be considered.

To meet this objective, several analyzes are planned including a speckle tracking echocardiography, allowing a non-invasive study of myocardial deformations.

The hypothesis is that two opposite weight disorders (anorexia nervosa and obesity) lead to similar complications: inflammation, fibrosis altering the myocardial structure and therefore its contractility. Both systolic and diastolic dysfunction appear. Investigator hypothesize that the determinants of this dysfunction involve part of the alteration of body mass, and partly qualitative alterations specific to each pathology.

Conditions

Interventions

BEHAVIORAL

echocardiography

* speckle tracking echocardiography * evaluation of cardiac variability by recording heart rate as several hours (POLAR watch) * bioimpedance * blood test for biological assays (metabolomic analysis)

Sponsors & Collaborators

  • University Hospital, Clermont-Ferrand

    lead OTHER

Principal Investigators

  • Justine Paysal · University Hospital, Clermont-Ferrand

Eligibility

Min Age
12 Years
Max Age
18 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-03-06
Primary Completion
2020-01-31
Completion
2020-01-31

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05071157 on ClinicalTrials.gov