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Heart Failure: Don't Forget the Role of Amyloidosis

NCT05501847 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 446

Last updated 2023-08-28

No results posted yet for this study

Summary

Heart failure is defined as the inability of the heart to provide sufficient output to meet the needs of the body.

It can occur in the course of a myocardial infarction, angina pectoris, hypertension, etc. Its frequency increases with age.

It is a major public health problem.

Heart failure first appears during exercise, then at rest. Initially, the heart tries to adapt to the loss of its contraction force by accelerating its beats (increase in heart rate), then it increases in volume (thickening of the walls or dilation of the cardiac cavities). This extra workload for the heart eventually leads to heart failure.

Cardiac amyloidosis is a possible cause of the disease in the West Indian population.

Cardiac amyloidosis is a rare disease related to our own proteins that will accumulate and cluster together to form abnormal protein deposits that will eventually lead to heart failure.

Cardiac amyloidosis particularly affects West Indians, due to the high frequency in this population of a genetic anomaly associated with the disease: the Valine 122 Isoleucine (Val122l) mutation of the transthyretin gene (protein transthyretin in which isoleucine is substituted for valine at position 122 (Ile 122)).

Early detection of amyloidosis appears essential for the implementation of appropriate therapies and therefore for an improvement in patient survival.

For this it seems important to better specify the frequency of cardiac amyloidosis in heart failure in the French West Indies.

Conditions

Interventions

RADIATION

Patient with no ventricular hypertrophy

Patients without LVH ≥ 12 mm will routinely receive a bone scan as part of the study. In case of cardiac fixation on bone scan, the patient will be managed as part of routine care according to a standardized care protocol that follows Guillmor's algorithm: monoclonal abnormality testing on biological blood samples +/- genotyping, in order to specify the senile or mutated character of TTR cardiac amyloidosis and to give the genotype.

Sponsors & Collaborators

  • University Hospital Center of Martinique

    lead OTHER

Principal Investigators

  • Astrid MONFORT BRAFINE, MD · CHU de Martinique

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-07-27
Primary Completion
2023-12-31
Completion
2024-06-30

Countries

  • Guadeloupe
  • Martinique

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05501847 on ClinicalTrials.gov