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Realistic Computational Electrophysiology Simulations for the Targetted Treatment of Atrial Fibrillation

NCT05057507 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 91

Last updated 2026-04-17

No results posted yet for this study

Summary

The aim of this research is to classify patients by the dominant mechanism of continuous atrial electrical activation during atrial fibrillation. This approach seeks to improve on existing classifications which are based solely on the duration of the arrhythmia (\<7 days, \>7 days and \>1 year). This is a cohort study. Patients undergoing clinically indicated electrophysiology study or AF ablation will have invasive assessment of cardiac electrophysiological profile at the time of their planned procedure, undergo 2-week ambulatory monitoring before and after the procedure, complete symptom questionnaires before and after their procedure and undergo atrial cardiac magnetic resonance imaging before their procedure.

Conditions

Interventions

DIAGNOSTIC_TEST

Atrial cardiac magnetic resonance imaging

To include assessment of atrial size, shape, function, fibrosis and fat

DIAGNOSTIC_TEST

Atrial electro-anatomic mapping

To include assessment of atrial voltage and local activation time

OTHER

Atrial fibrillation symptom questionnaire

To include assessment of atrial fibrillation symptoms and quality of life

DIAGNOSTIC_TEST

Patch-based 2 week ambulatory monitor

To assess atrial fibrillation burden post-ablation

Sponsors & Collaborators

Principal Investigators

  • Mark D O'Neill, FRCP · Guy's and St Thomas' NHS Foundation Trust

  • Neil Grubb, FRCP · NHS Lothian, Edinburgh

  • Andreas Rillig, MD · University Heart and Vascular Center, Hamburg

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-07-01
Primary Completion
2024-10-15
Completion
2026-07-31

Countries

  • United Kingdom

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05057507 on ClinicalTrials.gov