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miRNA in Sweat, a Novel Digital Biomarker for Detection of Active Tuberculosis (TB)

NCT05048381 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2023-11-01

No results posted yet for this study

Summary

The detection of miRNA (non-coding ribonucleic acid) in the blood in the context of active tuberculosis is an innovative approach to the detection of new disease-specific biomarkers.

The primary goal of this analysis is to define, for the first time, an miRNA fingerprint for tuberculosis in sweat. Samples that were collected as part of the Sweatb Study (NCT03667742) project are examined for the occurrence of disease-specific, non-coding miRNAs to define new biomarkers in the sweat. These biomarkers can be detected non-invasively and will help in the detection of patients with active tuberculosis.

Conditions

  • Active Tuberculosis

Interventions

DIAGNOSTIC_TEST

Next Generation Sequencing

Next Generation Sequencing of sweat and whole blood samples for non-coding miRNAs to define biomarkers that enable to differentiate between patients with active tuberculosis, a differential diagnostic disease and healthy individuals.

Sponsors & Collaborators

  • Fachhochschule Nordwestschweiz

    collaborator OTHER

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Jens Eckstein, Prof. Dr. med. · Chief Medical Information Office (CMIO), University Hospital Basel

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-09-06
Primary Completion
2022-10-31
Completion
2022-10-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05048381 on ClinicalTrials.gov