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Importance of the GH/IGF-1 Axis for Human Substrate and Energy Metabolism During Calorie Restriction

NCT01209429 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2011-09-13

No results posted yet for this study

Summary

This study will investigate whether growth hormone is modulated by the enzyme SIRT1 and by that is stimulating lipolysis on expense of IGF-I production. This is done in 10 healthy men on calorie restriction on 4 study days with fat and skeletal muscle biopsies.

Conditions

  • Healthy

Interventions

DRUG

GH hormone infusion

Norditropin 30 ng/kg/min

BEHAVIORAL

42 hour fast

The participant will be fasting 42 hours prior to the start of the study day, drinking water is allowed

BEHAVIORAL

12 hour fast

12 hour fast will be used as a control scenario to 42 hour fast

Sponsors & Collaborators

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Jens Otto L Jørgensen, Professor · University Hospital of Aarhus

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
FACTORIAL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-09-30
Primary Completion
2011-09-30
Completion
2011-09-30

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01209429 on ClinicalTrials.gov