MedTrace Logo

Assessing the Potential Role of the Gut Microbiome in Modulating Physical Abilities in Humans

NCT05024188 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2021-12-28

No results posted yet for this study

Summary

The intestinal microbiome is a microbial system that is influenced by host genetics and environmental exposures such as nutrition, stress and medications. There is a growing body of evidence indicating the significant contribution of the gut microbiome to host health and disease. Furthermore, it has been shown that exercise may modify the microbiome composition. However, important mechanistic questions related to the possible associations between exercise and the human gut microbiome remain unanswered.

In this study, the investigators are using advanced state-of-the-art measurements of physical activity level and related metabolic parameters whether there is a connection between the microbiome and physical abilities in healthy participants and whether antibiotics consumption can influence host physical abilities and glycemic responses through changes induced in microbiome composition and function.

Conditions

  • Physical Abilities
  • FMT

Interventions

DRUG

Antibiotics

Ciprofloxacin, 500 mg 2/day \& Metronidazole (Flagyl), 500 mg 3/day.

OTHER

Fecal Microbiota Transplantation

Fecal Microbiota Transplantation is the process of transferring stool from a healthy donor to another.

OTHER

Cellules Pills

7 days of cellules placebo pills.

OTHER

Agarose Capsules

Placebo capsules consist a combination of agarose in normal saline/glycerol (the same vehicle as in a FMT capsules)

Sponsors & Collaborators

  • Weizmann Institute of Science

    collaborator OTHER

  • Assaf Harofeh MC

    lead OTHER_GOV

Principal Investigators

  • Ilan Youngster, Dr. · Assaf-Harofeh MC, Bee'r Yaakov Israel

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-01-20
Primary Completion
2022-07-20
Completion
2023-01-20

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05024188 on ClinicalTrials.gov