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Restricted or Liberal Antibiotics After Appendectomy - Denver Health

NCT05002829 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 657

Last updated 2025-10-31

No results posted yet for this study

Summary

The purpose of this study is to see if decreasing the amount of antibiotics after appendicitis surgery can decrease the risk of adverse effects associated with antibiotics while at the same time ensuring participant safety.

Conditions

  • Appendicitis

Interventions

OTHER

Restricted Duration of SOC Antibiotic Use

Standard of Care Antibiotic use will be restricted to none or up to 24 hours of post-operative antibiotics.

OTHER

Liberal Duration of SOC Antibiotic Use

Standard of Care Antibiotic use will be permitted for 24 hours or up to 4 days of post-operative antibiotics.

Sponsors & Collaborators

  • Denver Health and Hospital Authority

    lead OTHER

Principal Investigators

  • Daniel D Yeh, MD, MHPE · Denver Health and Hospital Authority

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-11-01
Primary Completion
2025-07-16
Completion
2025-07-16

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05002829 on ClinicalTrials.gov