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Brain Mechanisms Supporting Cannabis-induced Pain Relief

NCT04982965 · Status: RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2026-06-03

No results posted yet for this study

Summary

Chronic low back pain is a common and disabling condition that affects millions of people in the United States. Many people with chronic low back pain do not get enough relief from current treatments. Cannabis may help reduce pain, but researchers do not fully understand how it affects the brain in people with chronic pain. The purpose of this study is to examine how inhaled cannabis changes brain activity and reduces pain in people with chronic low back pain. Results from this study may help researchers better understand how cannabis works for pain and support the development of improved pain treatments.

Conditions

  • Sciatica
  • Lumbar Radiculopathy
  • Lower Back Pain
  • Degenerative Disc Disease
  • Chronic Low-back Pain (cLBP)
  • Chronic Low Back and Leg Pain
  • Back Pain

Interventions

DRUG

Active Cannabis

400 mg of vaporized and inhaled active cannabis (5.1%)

DRUG

Placebo Cannabis

400 mg of vaporized and inhaled placebo cannabis (\<.1%)

Sponsors & Collaborators

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
21 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-05-07
Primary Completion
2027-01-15
Completion
2027-03-15
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04982965 on ClinicalTrials.gov