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Broad One Health Endectocide-based Malaria Intervention in Africa (BOHEMIA)

NCT04966702 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 48145

Last updated 2025-03-14

No results posted yet for this study

Summary

The BOHEMIA program consists of a combination of studies organized around a central community prevention mass drug administration protocol and four sub-studies (i.e.; social science, entomology, health economics, and environmental), each written as an individual protocol. The protocol is central but used in two separate, individually powered trials in Mozambique and Kenya. The trials have been powered on the efficacy outcome and designed to meet the requirements of World Health Organization's (WHO) preferred product characteristics (PPC) for endectocides.

Conditions

Interventions

DRUG

Albendazole Pill

Using a MDA approach, fieldworkers will administer albendazole using directly observed treatment methodology to participants

DRUG

Ivermectin Pill

Using a MDA approach, fieldworkers will administer ivermectin using directly observed treatment methodology to participants

DRUG

Ivermectin Injectable Product

Veterinary ivermectin injectable will be given to livestock in the relevant cluster

Sponsors & Collaborators

  • UNITAID

    collaborator OTHER

  • Barcelona Institute for Global Health

    lead OTHER

Principal Investigators

  • Regina Rabinovich · Barcelona Institute of Global Health

  • Carlos Chaccour · Barcelona Institute of Global Health

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
1 Week
Max Age
99 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-03-17
Primary Completion
2024-04-15
Completion
2024-10-03

Countries

  • Kenya
  • Mozambique

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04966702 on ClinicalTrials.gov