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Changes in Pregnancy in Egyptian Women With History of Recurrent Miscarriage

NCT04960982 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2021-07-14

No results posted yet for this study

Summary

Introduction: Elevated levels of androgen and insulin-resistant have been implicated in recurrent miscarriage in women with PCOS. Published data are scarce on androgen level and cervical length of women with and without PCOS and a history of miscarriage.

Aim: The aim of this study was to investigate the levels of testosterone (TT), Sex Hormone Binding Globulin (SHBG), Dehyroepiandrostenedione (DHEA) and cervical length in Egyptian women with and without history PCOS and history of RM during pregnancy .

Method: Pregnant women with (n=38) and without (n=40) PCOS and history of recurrent miscarriages were recruited from the Obstetrics Department, Alagoza Hospital, Cairo, Egypt. Healthy pregnant women without PCOS and history of RM (n=40, HC) were also recruited. TT, SHBG,DHEA and Sex Hormone Binding Globulin (SHBG) level and cervical length were assessed at first, second and the third trimester or at the start of miscarriage

Conditions

  • Polycystic Ovary Syndrome

Interventions

DIAGNOSTIC_TEST

blood test

blood sample is taken in first, second and third trimester of pregnancy

Sponsors & Collaborators

  • London Metropolitan University

    collaborator OTHER

  • Kafrelsheikh University

    lead OTHER

Principal Investigators

  • Essam El Mahdi, MD · London Metropolitan University

Eligibility

Min Age
23 Years
Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-03-01
Primary Completion
2020-09-01
Completion
2021-05-01

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04960982 on ClinicalTrials.gov