Ocular Surface Metabolo-lipidomics in Lateral Amyotrophic Sclerosis

Summary

Amyotrophic Lateral Sclerosis (ALS) is the most common neurodegenerative disease affecting the motor neuron. Currently, there is no diagnostic test and no examination that can predict the evolution of this pathology. The search for diagnostic and prognostic biomarkers is therefore essential for a better understanding of the pathophysiology of ALS, which remains poorly understood, and also for better clinical management. The ocular surface, made up of liquid elements, tears, and cells, is an accessible anatomical-physiological entity that has demonstrated its usefulness in the identification of biomarkers in neurodegenerative diseases such as Parkinson's or Alzheimer's. To date, no study has explored the ocular surface as a biomarker in ALS

Conditions

• Amyotrophic Lateral Sclerosis

Interventions

OTHER

Evaluation of the corneal innervation

Contact corneal confocal microscopy

OTHER

Slit lamp examination and undilated fundus

Slit lamp examination and undilated fundus

OTHER

Conjunctival impression

Conjunctival impression with anesthetic instillation

OTHER

Samples of basal tears

Collection of basal tears without instillation of anesthetic with a Schirmer strip for 5 minutes and by microcapillary

OTHER

Central corneal sensitivity

Central corneal sensitivity using a Cochet-Bonnet esthesiometer (Luneau©)

OTHER

Measure of visual acuity

ETDRS and Parinaud scale

OTHER

Interferometry

Non-contact exam measuring N.I.B.U.T (Non-invasive break-up time), quantitative and qualitative evaluation of the meibomian glands and quantitative evaluation of the tear meniscus

Sponsors & Collaborators

• University Hospital, Tours

  lead OTHER

Study Design

Allocation

NON_RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

100 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2021-09-17

Primary Completion

2023-09-30

Completion

2023-09-30

Countries

• France

Study Locations