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Differential Adaptation of Renal Function in Intense Physical Exercise

NCT04929418 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2026-04-30

No results posted yet for this study

Summary

In recent years there has been a significant increase in the number of participants in high intensity and duration sports events. This type of physical exercise has been reported to lead to an apparently transitory deterioration in kidney function. The injury mechanisms involved in this process have not been fully studied, but several have been proposed as potential causes, such as tissue ischemia, disruption of the permeability of the glomerular basement membrane, damage to the ultra-structure of skeletal muscle, structural involvement of the renal parenchyma, exercise-associated hyperthermia or insufficient hydration during exercise.

Urinary biomarkers, which are a more precise tool than serum creatinine when it comes to detecting subclinical kidney damage, may be key to elucidate the characteristics of exercise-related kidney injury.

The aim of this study is to carry out an integrative analysis of the development of exercise-associated subclinical acute kidney injury.

Conditions

Interventions

OTHER

10 km continuous running

Trial participants will perform a 10 km continuous running exercise

OTHER

1.5 km continuous swimming

Trial participants will perform a 1.5 km continuous swimming exercise.

Sponsors & Collaborators

  • Gerencia Regional de Salud de Castilla y Leon

    collaborator OTHER

  • Instituto de Investigación Biomédica de Salamanca

    collaborator OTHER

  • Centro Regional de Medicina Deportiva de Castilla y León

    collaborator UNKNOWN

  • Hospital Clínico Universitario de Valladolid

    lead OTHER

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-01-01
Primary Completion
2019-12-31
Completion
2020-03-20

Countries

  • Spain

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04929418 on ClinicalTrials.gov