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Ultra-high-frequency ECG for Prediction of Left Ventricular Remodeling

NCT04908033 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 368

Last updated 2025-03-05

No results posted yet for this study

Summary

The main goal of the project is to prove that ultra-high-frequency ECG (UHF-ECG) can be used as a diagnostic tool that allows the prediction of patients susceptible to the negative effect of right ventricular myocardial pacing. The prediction will be based on the assessment of electrical dyssynchrony and local depolarization durations of left ventricular depolarization emerging during right ventricular pacing. If proved to be valid in left ventricular negative remodeling prediction, UHF-ECG-derived parameters of ventricular dyssynchrony could be used as markers allowing a lead placement optimization during an implant procedure. This information can help the operator to identify patients with the urgent need for physiological pacing (HB or LBBp) and patients in which a right ventricular myocardial pacing is sufficient and will not lead to the development of the negative left ventricular remodeling.

Conditions

  • RV Pacing
  • Negative Remodeling
  • Dyssynchrony
  • UHF-ECG
  • Physiological Pacing

Interventions

DEVICE

pacemaker implantation

pacemaker implantation

Sponsors & Collaborators

  • St. Anne's University Hospital Brno, Czech Republic

    collaborator OTHER

  • Regional Hospital Liberec

    collaborator OTHER

  • Faculty Hospital Kralovske Vinohrady

    lead OTHER_GOV

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-05-01
Primary Completion
2025-06-01
Completion
2025-12-01

Countries

  • Czechia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04908033 on ClinicalTrials.gov