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Using Heart Electrical Signals to Study How Well Treatments Prevent Dangerous Heart Rhythms in Active People

NCT07014579 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2025-06-11

No results posted yet for this study

Summary

The goal of this observational study is to learn if two specific heart electrical signal patterns can help in detecting the risk of dangerous heart rhythms in athletes, and to see if exercise-based tests can be used instead of invasive hospital procedures to record this electrical signals.

The main questions it aims to answer are:

1. Can special ECG action potential duration markers (R2I2 and PERS) identify athletes who are at higher risk of sudden heart rhythm problems.
2. Can an exercise test give the same information as a non-invasive electrophysiology study.

Researchers will compare athletes who have an implanted heart device (ICD) with athletes who do not, to see if there are differences in these heart signals.

Participants will undergo:

1. ECG recordings during rest and exercise.
2. If they have an ICD or pacemaker, an ECG will be recorded during a non invasive stimulation.
3. A continuous 24 hour ECG.

Conditions

  • Inherited Cardiac Conditions
  • Sudden Cardiac Arrest
  • Ventricular Arrhythmia
  • Athlete
  • Ventricular Fibrillation

Sponsors & Collaborators

  • University of Leicester

    lead OTHER

Principal Investigators

  • Ghulam André Ng, MBChB, MRCP, Ph.D, FRCP · University of Leicester, Leicestershire, United Kingdom

  • Ghulam André Ng, MBChB, MRCP, Ph.D, FRCP, FHEA · University of Leicester, Leicestershire, United Kingdom

  • Xin Li, PhD, MSc, BSc, FHEA · University of Leicester, Leicestershire, United Kingdom

  • Harshil Dhutia, MBBS, BSC, MRCP, CCDS, MD(RES) · Glenfield Hospital, Leicester

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-06-01
Primary Completion
2026-07-31
Completion
2026-07-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07014579 on ClinicalTrials.gov