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Magnetic Resonance Imaging and Thermal Imaging of Adiposity in Neonates of Women With Metabolic Diseases

NCT04890886 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2021-05-18

No results posted yet for this study

Summary

There is limited knowledge about the extent of the impact of maternal metabolic diseases (MD) and/or alterations in maternal serum lipid content upon neonatal lipid distribution and phenotypes. This observational feasibility study aims to investigate the effect of maternal MD on fat distribution, lipid content and metabolic phenotype of different neonatal tissues. We will explore whether differences in tissue fat distribution and lipid content are observed in the neonates of women with MD during pregnancy, compared to those who have a healthy, uncomplicated pregnancy and if there are changes in how the different tissues work (e.g. cardiac function). If there is evidence to show that there are alterations during pregnancy in children of women with MD, this will help inform potential interventions to ensure optimal child health.

Conditions

Interventions

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Thermal imaging

Use of a thermal imaging cameral to measure brown and white adipose tissue function

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Echocardiogram

Echocardiographic imaging of the fetal heart to assess ventricular function

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ECG

ECG of the fetus and the neonate to look at the cardiac electrical activity

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MRI scan

MRI scan of the neonate to assess adipose tissue, liver architecture and cardiac structure and function

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Serum blood markers

Serum sample taken from mother before birth and umbilical cord or neonatal blood spot at birth to assess glucose levels / lipid levels and lipidomics and cardiac function (using NTproBNP) as a marker

Sponsors & Collaborators

Eligibility

Min Age
16 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-06-01
Primary Completion
2023-12-01
Completion
2023-12-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04890886 on ClinicalTrials.gov