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COllaboration REsearch on Chronic Cough (COREC): a French Multicenter Database

NCT04882943 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 178

Last updated 2026-04-14

No results posted yet for this study

Summary

Chronic cough (TC), defined by a duration exceeding 8 weeks, is a particularly frequent symptom with a prevalence observed at 9.6% 1. Chronic cough is the cause of a major handicap for patients with a impact on their quality of life 2.

Although CT is common, management is often delicate and complex. In studies, asthma, gastroesophageal reflux disease, posterior flushing, rhino-sinusitis, or taking tussigenic medications are common causes of chronic coughs. However, chronic refractory or unexplained cough, which corresponds to cough for which no cause has been found or the treatments directed against the cause of the cough have not made it possible to resolve the cough, is a real problem in practice. nick3.

There is currently no prospective data in France on the characteristics of chronic cough (etiologies, response to treatment) and the percentage of refractory cough.

The aim of the study is to constitute a French prospective multicenter hospital cohort of chronic cough patients in order to identify, for the first time in France in a prospective and multicenter manner, the frequency of patients with refractory cough among chronic cough patients.

Conditions

  • Refractory Chronic Cough

Interventions

OTHER

questionnaires

Quality of life questionnaires

Sponsors & Collaborators

  • University Hospital, Toulouse

    lead OTHER

  • MSD France

    collaborator INDUSTRY

Principal Investigators

  • Laurent GUILLEMINAULT · University Hospital, Toulouse

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-06-22
Primary Completion
2025-11-25
Completion
2026-04-02

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04882943 on ClinicalTrials.gov