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Effect of L-Citrulline Supplementation on NAFLD in Adolescents With Obesity

NCT04871360 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 42

Last updated 2022-01-19

No results posted yet for this study

Summary

One of the comorbidities of obesity is nonalcoholic fatty liver disease (NAFLD). L-citrulline is a non-protein amino acid that has shown positive effects on the degree of fat retention and metabolic profile in NAFLD. The objective is to assess the effect of oral L-citrulline supplementation on liver function and nonalcoholic fatty liver in adolescents with obesity. A clinical study will be carried out in 40 adolescents (15-19 years) with obesity, they will be divided into a control group that will receive a placebo and an experimental group that will receive 6 g of l-citrulline per day for eight weeks.

Conditions

  • Non-Alcoholic Fatty Liver Disease
  • Obesity

Interventions

DIETARY_SUPPLEMENT

L-Citrulline supplement

The intervention will consist of oral supplementation of six grams of pure l-citrulline for eight weeks.

DIETARY_SUPPLEMENT

Carboxymethyl cellulose supplement

The intervention will consist of oral carboxymethyl cellulose supplementation as a placebo.

Sponsors & Collaborators

  • Universidad de Guanajuato

    lead OTHER

Principal Investigators

  • Ma. E Garay-Sevilla, PhD · Universidad de Guanajuato

  • Verónica I Tovar-Villegass, Bachelor · Universidad de Guanajuato

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
15 Years
Max Age
19 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-05-05
Primary Completion
2021-12-19
Completion
2022-01-15

Countries

  • Mexico

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04871360 on ClinicalTrials.gov