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Colorectal Metastasis and Liver Transplantation With Organs From Deceased Donors

NCT04870879 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 18

Last updated 2021-05-04

No results posted yet for this study

Summary

MELODIC trial is an prospective, multicenter, non-randomized, open-label, parallel trial, aimed at assessing the efficacy (in terms of overall survival: OS) of liver transplantation (LT) in unresecable CRC liver-only metastases, compared with a matched cohort of patients bearing the same tumor characteristics, and treated with chemotherapy. Synthesis of Inclusion parameters: "10;10;10;100"

Conditions

  • Colorectal Liver Metastases
  • Colorectal Adenocarcinoma
  • Unresectable Malignant Neoplasm

Interventions

PROCEDURE

Liver Transplant

Liver Transplant from cadaveric donors

DRUG

Chemotherapy

Chemotherapy

Sponsors & Collaborators

  • Istituto Oncologico Veneto IRCCS

    collaborator OTHER

  • Azienda Ospedaliera di Padova

    lead OTHER

Principal Investigators

  • Umberto Cillo, MD · U.O.C Chirurgia Epatobiliare e dei Trapianti Epatici, AOPD

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-10-01
Primary Completion
2025-10-31
Completion
2025-10-31

Countries

  • Italy

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04870879 on ClinicalTrials.gov