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Risk Factors for Barotrauma in COVID-19

NCT04859881 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 262

Last updated 2021-04-26

No results posted yet for this study

Summary

Barotrauma in mechanical ventilation (MV) is defined as lung damage attributable to the application of high airway pressure and is one of the potential mechanisms of ventilator-induced lung injury (VILI). Previous studies have shown an increased mortality in patients with barotrauma under MV; pneumothorax (PTX) being the most common presentation, but it can also present as pneumomediastinum (PM) with or without PTX, with extension to soft tissue as subcutaneous emphysema or even as pneumo-retroperitoneum and pneumo-scrotum.

Traditionally, underlying lung disease or age are known risk factors for non-trauma related barotrauma. However, in patients with novel coronavirus disease (COVID-19), the incidence of this complication is more common than in non-infected patients, as recently reported. Since little is known regarding which are the main risk factors for these events to develop, most pathophysiological mechanisms remain unexplained.

The aim of this study was to determine the risk factors for developing barotrauma in patients under MV with COVID-19 associated Acute Respiratory Distress Syndrome (ARDS). Secondary objectives were to determine the incidence of barotrauma and its association with mortality.

Conditions

  • Barotrauma
  • Covid19

Interventions

OTHER

No intervention

No intervention

Sponsors & Collaborators

  • Horacio Marquez-Gonzalez

    collaborator UNKNOWN

  • Carlos Torruco-Sotelo

    collaborator UNKNOWN

  • Sebastian Rodriguez-Llamazares

    collaborator UNKNOWN

  • Hospital General Ajusco Medio

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-04-01
Primary Completion
2021-01-31
Completion
2021-01-31

Countries

  • Mexico

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04859881 on ClinicalTrials.gov