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Ventilator-induced Lung Injury Vortex in Patients With SARS-CoV-2

NCT04174313 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 65

Last updated 2021-08-30

Study results available
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Summary

The concept of Ventilator-induced Lung Injury Vortex (VILI vortex) has recently been proposed as a progressive lung injury mechanism in which the alveolar stress/strain increases as the ventilable lung "shrinks" (1). This positive feedback inexorably leads to the acceleration of lung damage, with potentially irreversible results. Little is known about the clinical aspects of this condition. Understanding its behavior could contribute to changing its potential devastating impact.

The objective of this study is to evaluate the incidence of VILI vortex in patients with acute respiratory syndrome (ARDS) secondary to COVID-19, to establish a connection between this phenomenon and mortality, and to identify the factors that have an impact on its development.

Conditions

  • ARDS
  • Mechanical Ventilation Complication
  • Ventilator-Induced Lung Injury

Interventions

DIAGNOSTIC_TEST

CT scan

Mechanical variables and PaO2/FiO2 were registered daily for 14 days or until initiating assisted ventilation. These data were obtained in passive mechanical conditions. Ventilator-induced lung injury vortex was defined as a progressive increase in driving pressure (ΔP) as Vt remained constant or even decreased. Refractory hypoxemia was defined as PaO2/FiO2 \<100 despite the optimization of mechanical ventilation and prone positioning.

Sponsors & Collaborators

  • Hospital El Cruce

    lead OTHER

Principal Investigators

  • Nestor Pistillo · Hospital El Cruce

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-03-10
Primary Completion
2021-03-11
Completion
2021-06-09

Countries

  • Argentina

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04174313 on ClinicalTrials.gov