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Comprehensive Assessment of Interconnection Between Brain Emotional Activity and Coronary Plaque Instability

NCT04853511 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2022-08-24

No results posted yet for this study

Summary

Emotional stress is associated with future cardiovascular events. However, the biological interconnection between brain emotional neural activity and acute plaque instability is not fully understood. Optical coherence tomography-Fluorescence Lifetime (OCT-FLIM) dual modal intravascular imaging is a novel technique that enables comprehensive assessment of structural and biochemical characteristics of coronary atheroma and estimates the level of plaque instability. 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) enables simultaneous estimation of multi-system activities including emotional stress, arterial inflammation, and hematopoiesis. The present study aims to prospectively investigate mechanistic linkage between coronary plaque instability, stress-associated neurobiological activity, and macrophage hematopoiesis using OCT-FLIM and 18F-FDG PET/CT imaging assessment.

Conditions

  • Atherosclerosis, Coronary
  • Emotional Stress
  • Inflammation
  • Hematopoiesis
  • Atherosclerosis Coronary Artery With Angina Pectoris
  • Atheroma; Heart
  • Atherosclerosis
  • Acute Coronary Syndrome

Interventions

DEVICE

OCT-FLIM (optical coherence tomography-fluorescence life time)

comprehensive assessment of coronary plaque with OCT-FLIM dual modal intravascular catheter imaging followed by serial 18F-FDG-PET/CT imaging

Sponsors & Collaborators

  • Korea University Guro Hospital

    lead OTHER

Principal Investigators

  • Jin Won Kim, MD, PhD · Korea University Guro Hospital

  • Dong Oh Kang, MD, PhD · Korea University Guro Hospital

  • Sun Won Kim, MD, PhD · Korea University

  • Hongki Yoo, PhD · Korea Advanced Institute of Science and Technology

Eligibility

Min Age
20 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-02-14
Primary Completion
2023-12-31
Completion
2024-12-31

Countries

  • South Korea

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04853511 on ClinicalTrials.gov