Mitochondrial Stress, Brain Imaging, and Epigenetics

Summary

The MiSBIE study collects biological, behavioral, psychosocial, neuropsychological, and brain imaging data in participants with either: normal mitochondrial function, individuals with the m.3243A\>G mitochondrial DNA (mtDNA) mutation, and individuals a single large-scale mtDNA deletion. These defects induce mitochondrial allostatic load (MAL). The 2-day protocol, plus home-based data collection, will provide a comprehensive assessment of the multi-systemic dysregulation associated with MAL or mitochondrial dysfunction, and the link to physical and mental health-related symptoms.

Aim 1: Determine the influence of MAL on systemic AL biomarkers.

Aim 2: Establish the influence of MAL on stress reactivity profiles.

Aim 3. Examine the association between MAL and psychological functioning.

Conditions

• Mitochondrial Diseases

Interventions

BEHAVIORAL

Trier social stress test

The Trier social stress test (TSST) is a tool for investigating psychobiological stress responses in a laboratory setting. It is a laboratory procedure used to reliably induce stress in human research participants. The study is not examining or validating the test itself but rather using it as a tool to measure the response/focus of study.

Sponsors & Collaborators

• Dartmouth College

  collaborator OTHER

• Centre National de la Recherche Scientifique, France

  collaborator OTHER

• Massachusetts General Hospital

  collaborator OTHER

• Technische Universität Dresden

  collaborator OTHER

• National Institute of Mental Health (NIMH)

  collaborator NIH

• Columbia University

  lead OTHER

Principal Investigators

• Martin Picard, PhD · Columbia University

Study Design

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

60 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2018-06-12

Primary Completion

2023-06-30

Completion

2024-05-03

Countries

• United States

Study Locations